Prednisolone What is it for, Side Effects and How to Take


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Prednisolone is an anti-inflammatory steroid meant for the treatment of diseases such as rheumatism, hormonal changes, collagenoses, allergies and problems affecting the skin and eyes, generalized swellings, problems in the blood, respiratory, gastrointestinal and neurological problems and infections. In addition, this remedy can also be used in cancer treatment.

This medicine is available in form of tablets, oral suspension or drops. It can be purchased in pharmacies upon presentation of a prescription.

What is it for?

Prednisilone is a remedy that acts as an anti-inflammatory and an immunosuppressive. It is meant for the treatment of diseases where inflammatrory and autoimmune processes occur, treatment of endocrine problems and it is used together with other medicines for the treatment of cancer.

Prednisilone is used in the following cases:

  • Endocrine disorders such as adrenocortical insufficiency, congenital adrenal hyperplasia, non-suputive thyroiditis, and cancer-associated hypercalcemia
  • Rheumatism such as psoriatic or rheumatoid arthritis, ankylosing spondylitis, bursitis, nonspecific acute tenosyllitis, acute gouty arthritis, posttraumatic osteoarthritis, osteoarthritic synovites, and epicondylitis;
  • Collagenoses, particularly in cases of systemic lupus erythesis and acute rheumatic carditis
  • Skin diseases such as pemphigus, some dermatitis, mycoses and severe psoriasis
  • Allergies such as allergic rhinitis, contact and atopic dermatitis, serum diseases and hypersensitivity reactions to drugs
  • Ophthalmic diseases, such as allergic marginal ulcers of the cornea, ophthalmic herpes zoster, inflammation of the anterior segment, diffuse posterior coroiditis, sympathetic ophthalmia, allergic conjunctivitis, ceratitis, coriorretinitis, optic neuritis, iritis and iridocyclitis
  • Respiratory diseases such as symptomatic sarcoidosis, Löefler syndrome, berylliosis, some cases of tuberculosis, aspiration pneumonitis and bronchial asthma
  • Blood disorders such as idiopathic thrombocytopenic purpura and secondary thrombocytopenia in adults, acquired hemolytic anemia, erythrocyte anemia, and erythroside anemia
  • Cancer, in the palliative treatment of leukemias and lymphomas.

Moreover, prednisilone can also be used in the treatment of acute exacerbations of sclerosis so as to reduce swelling in cases of idiopathic nephrotic syndrome and lupus erythesus and also for the maintanance of a patient who has suffered from ulcerative colitis or regional enteritis.

How to take

The dosage of prednisilone varies greatly as it depends on weight, age, disease to be treated and the pharmaceutical form. All these should be determined by a doctor.

1. 5 or 20 mg tablets

  • Adults: The starting dosage ranges from 5 to 60 mg per day, the equivalent of 1 5 mg tablet or 3 tablets of 20 mg.
  • Children: The starting dosage ranges from 5 to 20 mg per day, the equivalent of 1 5 mg tablet or 1 20 mg tablet.

The dosage should be gradually reduced once it has been administered for more than a few days. Tablets should be swallowed whole with a glass of water without breaking or chewing.

2. Syrup of 3 mg/mL or 1 mg/mL

  • Adults: The recommended dosage ranges from 5 to 60 mg per day;
  • Infants and Children: The recommended dosage ranges from 0.14 to 2 mg per 1 kg of weight of the child, per day, divided into 3 to 4 daily administrations

The concentration of the oral solution determines the volume to be measured since there are two diferent presentations.Once given for a few days, the dosage should be reduced gradually.

3. Solution in drops of 11 mg/mL

  • Adults: The recommended dosage ranges from 5 to 60 mg per day, equivalent to 9 drops or 109 drops, per day.
  • Children: The recommended dosage ranges from 0.14 to 2 mg per 1 kg of weight of the child, given 1 to 4 times a day.

Each drop is equivalent to 0.55 mg of prednisolone. The dosage should be reduced gradually once it is given for more than a few days.

The doctor should always indicate the recommended dosage and duration of treatment with prednisilone as it depends on the problem to be treated, age an the individual response of the patient being treated.

Side effects

The most common side effects during treatment with prednisilone are increased appetite, poor digestion, pepetic ulcer, pancreatitis and ulcerative esophagatis, nervousness, fatigue and insomnia.

In addition, patients may also experience allergic reactions, eye disorders such as cataracts, glaucoma, exophthalmos and intensification of secondary infections by fungi or eye viruses, reduced tolerance to carbohydrates, manifestation of latent diabetes mellitus and increased insulin needs or oral hypoglycemic agents in diabetes.

A sharp increase in tryglycerides in the blood may also be noted due to treatment with high doses of carticosteroids.

Contraindications

Prednisolone is contraindicated for people with systemic fungal infections or uncontrolled infections and for patients with allergy to prednisolone or any of the formula components.

This medicine should also not be used by pregnant or nursing women unless recommended by the doctor.

What is the difference between prednisolone and prednisone?

Prednisone is a prodrug of prednisolone. Prednisone is therefore an inactive form that needs to be transformed to prednisilone in the liver for it to exert its action.

Thus, if a person ingests either prednisone or prednisilone, the action exerted by the drug will be the same as prednisone will be transformed and activated in the liver to prednisilone. For this reason, prednisilone posses an advantage to people with liver problems as it does not need to be transformed in the liver for it to exert its activity in the body.


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